SHIRE PLC: Block Listing Application

Block Listing Application 
November 12, 2012 - Shire plc (the "Company") (LSE: SHP, NASDAQ: SHPG) hereby
notifies the market that application has been made to the UK Listing Authority
and the London Stock Exchange for a total of 110,000 ordinary shares of 5p each
("Shares") to be admitted to the Official List. These Shares are being reserved
under a block listing and will be issued to satisfy awards granted under the
Shire Sharesave Scheme. 
These shares will rank pari passu in all respects with the existing issued
Shares of the Company.  
For further information please contact: 
Investor          Eric Rojas (              +1 781 482 0999   

                  Sarah Elton-Farr (    +44 1256 894157   

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of:

  * Behavioral Health and Gastro Intestinal conditions
      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
-0- Nov/12/2012 07:00 GMT
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