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AstraZeneca Launches New Digital Resources for ARIMIDEX® (anastrozole) Tablets to Help Educate Patients About ARIMIDEX Direct



  AstraZeneca Launches New Digital Resources for ARIMIDEX® (anastrozole)
  Tablets to Help Educate Patients About ARIMIDEX Direct

  Resources Provide Program Enrollment Information and Encourage Patients to
                      Share the Information With Others

Business Wire

WILMINGTON, Del. -- November 12, 2012

AstraZeneca (NYSE: AZN) today launched new digital resources to educate
patients on how to enroll in ARIMIDEX Direct. Resources include a “how to”
video outlining the enrollment process for ARIMIDEX Direct and a digital badge
that can be shared via social media platforms and symbolizes support for the
program.

Breast cancer treatments can impact patients financially. In fact, research
has found that the estimated lifetime costs of medical care for breast cancer
patients in the United States can be up to $100,000.^1 However, there are
programs like AstraZeneca’s ARIMIDEX Direct, which can help reduce financial
strain for patients taking ARIMIDEX.

ARIMIDEX is approved for adjuvant treatment (treatment following surgery with
or without radiation) of postmenopausal women with hormone receptor-positive
early breast cancer. Prescription ARIMIDEX is only for postmenopausal women.
ARIMIDEX should not be taken if you are pregnant because it may harm your
unborn child. Do not take ARIMIDEX if you are allergic to any of its
ingredients. Additional Important Safety Information provided below.

ARIMIDEX Direct enables eligible patients with a valid prescription to have
ARIMIDEX^® (anastrozole) Tablets delivered directly to their home for $40 per
month, including shipping and handling. Patients who enroll in ARIMIDEX Direct
could save more than $4,000 per year through the program. ARIMIDEX Direct is
not valid for prescriptions purchased under Medicaid or similar assistance
programs.

ARIMIDEX Direct is a development in AstraZeneca’s long tradition of innovation
in oncology. Over the years, AstraZeneca has produced treatment options in the
therapeutic area of oncology, including medications for treating
postmenopausal women with hormone receptor-positive early breast cancer.
Further, AstraZeneca has long played a leadership role in raising awareness
about breast cancer and the importance of screening. The AstraZeneca
Foundation was one of the founders of National Breast Cancer Awareness Month.
In addition, AstraZeneca is proud to be an award recipient of the CEO Gold
Standard Accreditation from the CEO Roundtable on Cancer since 2006.

Patients or physicians with questions can call 1-800-637-3616 to contact
ARIMIDEX Direct  Customer Service between 8:00 AM and 6:00 PM ET, Monday
through Friday, excluding holidays.

Important Safety Information About ARIMIDEX^® (anastrozole) Tablets

  * Based on information from a study in patients with early breast cancer,
    women with a history of blockages in heart arteries (ischemic heart
    disease) who take ARIMIDEX may have a slight increase in this type of
    heart disease compared to similar patients who take tamoxifen
  * ARIMIDEX can cause bone softening/weakening (osteoporosis) increasing the
    chance of fractures. In a clinical study in early breast cancer, there
    were more fractures (including fractures of the spine, hip, and wrist)
    with ARIMIDEX (10%) than with tamoxifen (7%)
  * In a clinical study in early breast cancer, some patients taking ARIMIDEX
    had an increase in cholesterol. Skin reactions, allergic reactions, and
    changes in blood tests of liver function have also been reported
  * In the early breast cancer clinical trial, the most common side effects
    seen with ARIMIDEX include hot flashes, joint symptoms (including
    arthritis and arthralgia), weakness, mood changes, pain, back pain, sore
    throat, nausea and vomiting, rash, depression, high blood pressure,
    osteoporosis, fractures, swelling of arms/legs, insomnia, and headache
  * In advanced breast cancer trials, the most common side effects seen with
    ARIMIDEX versus tamoxifen include hot flashes, nausea, decreased energy
    and weakness, pain, back pain, headache, bone pain, increased cough,
    shortness of breath, sore throat, and swelling of arms and legs. Joint
    pain/stiffness has been reported in association with the use of ARIMIDEX
  * ARIMIDEX should not be taken with tamoxifen or estrogen-containing
    therapies

Approved Uses for ARIMIDEX^® (anastrozole) Tablets

ARIMIDEX is approved for adjuvant treatment (treatment following surgery with
or without radiation) of postmenopausal women with hormone receptor-positive
early breast cancer.

ARIMIDEX is approved for the initial treatment of postmenopausal women with
hormone receptor-positive or hormone receptor-unknown locally advanced or
metastatic breast cancer and for the treatment of postmenopausal women with
advanced breast cancer that has progressed following treatment with tamoxifen.
Patients with hormone receptor-negative disease and patients who did not
previously respond to tamoxifen therapy rarely responded to ARIMIDEX.

Click here for the full Prescribing Information for ARIMIDEX.

For more information, see your doctor.

You are encouraged to report negative side effects of prescription drugs to
the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business with a
primary focus on the discovery, development, and commercialization of
prescription medicines for gastrointestinal, cardiovascular, neuroscience,
respiratory and inflammation, oncology, and infectious disease. AstraZeneca
operates in over 100 countries and its innovative medicines are used by
millions of patients worldwide. For more information please visit:
www.astrazeneca.com.

For more information about AstraZeneca in the US or our AZ&Me™ Prescription
Savings programs, please visit www.astrazeneca-us.com or call 1-800-AZandMe
(292-6363).

                                   – ENDS –

                                                                 1978200 10/12

^1 Campbell J, Ramsey S. The costs of treating breast cancer in the US: A
synthesis of published evidence. Pharmacoeconomics. 2009; 27(3): 199-209.

Photos/Multimedia Gallery Available:
http://www.businesswire.com/multimedia/home/20121112006129/en/

Multimedia
Available:http://www.businesswire.com/cgi-bin/mmg.cgi?eid=50474347&lang=en

Contact:

AstraZeneca
Media Inquiries
Stephanie Andrzejewski, +1 302-885-8896
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