SHIRE PLC: Transaction in Own Shares

Transaction in Own Shares 
November 7, 2012 - Shire plc (the "Company") (LSE: SHP, NASDAQ: SHPG) announces
that in accordance with the authority granted by shareholders at the Company's
Annual General Meeting on April 24, 2012 it purchased 130,255 of its ordinary
shares of 5 pence each on November 7, 2012. The highest and lowest price paid
for these shares was 1800.00 pence per share and 1765.00 pence per share
respectively. 
The purchased shares will be held as treasury shares. Following the above
purchase, the Company holds 834,865 shares as treasury shares, and has
561,706,022 shares in issue (excluding treasury shares). 
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 


      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.
                                                                              

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     


                                              
www.shire.com        
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-0- Nov/07/2012 18:10 GMT