Ocular Therapeutix Demonstrates Two-Month IOP Reduction with Sustained Release
Travoprost for the Treatment of Glaucoma
BEDFORD, Mass., Oct. 30, 2012
BEDFORD, Mass., Oct. 30, 2012 /PRNewswire/ --Ocular Therapeutix, Inc.
announced promising results of their sustained release travoprost (OTX-TP2)
study for the treatment of glaucoma and ocular hypertension. OTX-TP2, a
drug-eluting intracanalicular plug inserted through the punctum, was evaluated
for the reduction of elevated intraocular pressure over a two-month period.
The pilot Phase II study enrolled twenty patients (36 eyes) at the Umhlanga
Hospital Medical Centre and Netcare Alberlito Hospital in South Africa.
Patients with documented open-angle glaucoma or ocular hypertension
(intraocular pressure (IOP)>/= 24 mmHg and</= 34 mmHg) were enrolled in the
study, with a mean IOP at baseline of 28.7 mmHg. A single plug was
administered in each enrolled eye. Analysis showed a decrease in IOP of 6.8
mmHg over two months of treatment. No excessive tearing or other
unanticipated adverse events occurred.
Mean IOP Reduction
(mm Hg) (mm Hg)
Baseline 28.7 -
Day 15 21.4 7.2
Day 30 22.1 6.6
Day 45 21.9 6.7
Day 60 21.8 6.8
Results are comparable to topical brand name ophthalmic solutions, Travatan®
(Alcon Laboratories, Inc.), Lumigan® (Allergan, Inc.), and Xalatan® (Pfizer,
Inc.).^1 However, current topical administrations are plagued with issues of
non-compliance, which can lead to costly and invasive surgeries, vision
impairment, and even blindness. It has been reported that up to 60% of
patients do not administer ophthalmic drops as directed, even though patients'
perception is that they are compliant with 97% of their dosing.^2 Sustained
release travoprost may help to circumvent these issues of patient
non-compliance by eliminating the need for daily dosing.
"Not only did the plug deliver therapeutic amounts of drug over two months,
reduction in intraocular pressure remained consistent and significant
throughout the entire treatment period" stated Pierre Wassermann, Principal
Investigator at the Umhlanga Hospital Medical Centre in South Africa. "This
product has the potential to revolutionize management of the disease by
putting drug dosing in the hands of the physician rather than the patient."
Glaucoma is a chronic disease that must be monitored and treated for life,
impacting more than 2 million Americans, and is the leading cause of blindness
in the United States. "Achieving clinically meaningful IOP reduction over a
two-month period with single-dose administration is a tremendous achievement"
stated Amar Sawhney, President and CEO of Ocular Therapeutix, Inc. "We are
optimistic about recent advances in extending delivery, visualization, and
persistence of our formulations to longer durations."
About Ocular Therapeutix's Drug Products:
Ocular Therapeutix uses the company's proprietary polyethylene glycol hydrogel
intracanalicular plug technology to release proven and approved drugs in a
sustained fashion over a specified period of time. At the end of the
treatment period, the plug begins to absorb, and exits the nasolacrimal system
without need for removal by the physician. The plugs contain a visualization
agent for retention monitoring throughout the treatment period.
About Ocular Therapeutix, Inc.:
Founded in November 2006, Ocular Therapeutix, Inc. is a privately held company
based in Bedford, MA, focused on the development and commercialization of
ophthalmic therapeutic products using its proprietary hydrogel technology.
Ocular Therapeutix is using its hydrogel technology for development of a
variety of ophthalmic applications including hydrogel sealants for ocular
surface protection, drug-eluting punctum plugs for treatment of various
anterior segment diseases, and with therapeutic agents for back-of-the-eye
^1Package Inserts: Xalatan® 0.005% latanoprost ophthalmic solution, Pfizer,
Woodstock, IL, USA. 2011; Lumigan® 0.01% and 0.03% bimatoprost ophthalmic
solution, Allergan, Irvine, CA, USA. 2012; Travatan Z® 0.004% travoprost
ophthalmic solution, Alcon, Fort Worth, Texas, USA. 2010.
^2Goldberg I. Compliance with Medical Management in Glaucoma. Asian J of
SOURCE Ocular Therapeutix, Inc.
Contact: Scott Corning, Vice President of Marketing and Sales,
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