Apricus Biosciences Receives $2.5 Million Payment From Abbott Laboratories for Vitaros(R) in Canada

Apricus Biosciences Receives $2.5 Million Payment From Abbott Laboratories for
Vitaros(R) in Canada

SAN DIEGO, Oct. 18, 2012 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc.
("Apricus Bio" or the "Company") (Nasdaq:APRI) (http://www.apricusbio.com)
announced today that it received a $2.5 million payment from Abbott
Laboratories Limited ("Abbott") under its commercial partnership for Apricus
Bio's Vitaros® drug for erectile dysfunction ("ED") in Canada. Also, Apricus
Bio successfully produced six consecutive commercial size validation batches
of Vitaros^®, the Company's treatment for ED in 220 mcg and 330 mcg forms.

"The successful manufacturing of Vitaros® has been a great accomplishment for
Apricus Bio as this was the first time that this drug has been manufactured on
a commercial scale," said Dr. Bassam Damaj, the Company's President and Chief
Executive Officer."This is an important step in placing Vitaros^® into the
hands of urologists in Canada and represents another completed milestone in
our strategic collaboration with Abbott and in our global commercial strategy
for Vitaros^®. Now that we have completed our commercial size validation
batches for Canada, our manufacturing team is focusing on producing additional
Vitaros® commercial batches for Abbott in Canada and for our U.S. partner,
Warner Chilcott, as disclosed by us recently."

Dr. Damaj continued, "We believe that Vitaros^® will be an attractive
alternative for many patients with erectile dysfunction, both for its safety
profile and rapid onset.We look forward to giving erectile dysfunction
patients in Canada and in other countries the choice of a new non PDE5 based
drug. These attributes have contributed to its licensing in a variety of
territories by world-class pharmaceutical companies including Abbott, Takeda,
Novartis-Sandoz, Warner Chilcott, Bracco, Elis and Neopharm."

About Vitaros^® and the Canadian ED Market

According to IMS Health data, the annual ED market in Canada in 2010 was
approximately $180 million (CAD). The current leading medications are
sildenafil citrate, tadalafil and vardenafil HCI which are taken in pill form
and work by inhibiting an enzyme called PDE5.

There is still a need for new, safe and effective treatments, however,
especially for those patients who cannot or do not respond well to oral
medications. Vitaros^® is applied topically which helps to reduce side effects
and offers men who do not do well with the existing oral drugs a
patient-friendly alternative. When absorbed through the skin, Vitaros^®
directly boosts blood flow, thereby causing an erection within minutes -- much
faster than the results achieved from the oral medications.

The key innovation behind Vitaros^® was combining alprostadil with Apricus
Bio's NexACT® delivery technology, which allows the drug to pass through the
skin and makes the treatment much easier to apply and provide patients with a
safer alternative treatment.

In clinical studies, Vitaros^® worked in patients suffering from mild to
severe ED, including men who did not respond to sildenafil citrate. The side
effects reported were localized and transient.

About Apricus Biosciences, Inc.

Apricus Bio (Nasdaq:APRI) is a pharmaceutical company that develops and
markets innovative treatments that help large patient populations across
numerous, high-demand therapeutic classes. The Company has four approved
products and has developed a strong pipeline of multiple late-stage product
candidates. With commercial operations in both the U.S. and Europe (France),
Apricus Bio generates revenues and growth from sales of its commercial
products and by out-licensing, in certain territories, its pipeline products
and NexACT^® technology.

Apricus Bio's growth strategy is to acquire, develop, and commercialize new
products through strategic partnerships. The Company currently has commercial
partnerships with multiple large pharmaceutical companies including Novartis,
Takeda, Abbott Laboratories, Sandoz, Warner Chilcott and Bracco, and
co-promotes multiple products in France.

Apricus Bio is headquartered in San Diego, CA and is publicly traded on the
NASDAQ Capital Market under the ticker symbol APRI.

For further information on Apricus Bio, visit http://www.apricusbio.com, and
for information on its subsidiary please visit http://www.nexmedusa.com. You
can also receive information at http://twitter.com/apricusbio.

CONTACT: Apricus Bio Investor Relations:
        
         David Pitts
         Argot Partners
         212-600-1902
         david@argotpartners.com

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