Isis Pharmaceuticals to Present a General Corporate Update at Its 2012 Annual Meeting of Stockholders and Open House

Isis Pharmaceuticals to Present a General Corporate Update at Its 2012 Annual                     Meeting of Stockholders and Open House  PR Newswire  CARLSBAD, Calif., June 5, 2012  CARLSBAD, Calif., June 5, 2012 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS), the leader in antisense therapeutics, today announced that management will present a general corporate update in conjunction with its 2012 Annual Meeting of Stockholders and Open House on Thursday, June 7 at 2:10 p.m. Pacific Time in Carlsbad, CA.  The agenda for the meeting is as follows:    o2:00 p.m. – 2:10 p.m. Annual Meeting of Stockholders (only for     stockholders of record as of April 9, 2012)   o2:10 p.m. – 3:00 p.m. Corporate Presentation – Stanley T. Crooke, Isis     Chairman and Chief Executive Officer   o3:00 p.m. – 5:00 p.m. Scientific Poster Presentation  A live audio webcast of the presentation will be available on the "Investors & Media" section of the Company's Web site, www.isispharm.com. A replay of the presentation will be available on the Isis Web site within 48 hours and will be archived for a limited time.  To RSVP to attend the meeting, please go to Isis' Home Page at www.isispharm.com.  ABOUT ISIS PHARMACEUTICALS, INC. Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners. Isis' broad pipeline consists of 25 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic, severe and rare diseases, and cancer. Isis' partner, Genzyme, plans to commercialize Isis' lead product, KYNAMRO, following regulatory approval, which is expected in 2012. Isis' patents provide strong and extensive protection for its drugs and technology. Additional information about Isis is available at www.isispharm.com.  SOURCE Isis Pharmaceuticals, Inc.  
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