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Amgen's Full Year 2011 Revenue Increased 4 Percent to $15.6 Billion and Adjusted Earnings Per Share (EPS) Increased 2 Percent to



   Amgen's Full Year 2011 Revenue Increased 4 Percent to $15.6 Billion and
        Adjusted Earnings Per Share (EPS) Increased 2 Percent to $5.33

Full Year 2011 GAAP EPS Decreased 16 Percent to $4.04 Due to a One-Time Charge

2012 Total Revenue and Adjusted EPS Expected to be in the Range of $16.1-$16.5
Billion and $5.90-$6.15, Respectively

PR Newswire

THOUSAND OAKS, Calif., Jan. 26, 2012

THOUSAND OAKS, Calif., Jan. 26, 2012 /PRNewswire/ -- Amgen (NASDAQ: AMGN)
reported total revenue increased 3 percent during the fourth quarter of 2011
to $3,973 million versus $3,841 million in the fourth quarter of 2010.  For
the full year 2011, total revenue increased 4 percent to $15,582 million from
$15,053 million in 2010.

Adjusted earnings per share (EPS) were $1.21 for the fourth quarter of 2011,
an increase of 3 percent compared to $1.17 for the fourth quarter of 2010.
 Adjusted net income decreased 6 percent to $1,039 million in the fourth
quarter of 2011 compared to $1,103 million in the fourth quarter of 2010.

Full year 2011 adjusted EPS were $5.33 versus $5.21 in 2010, a 2 percent
increase.  Full year 2011 adjusted net income decreased 3 percent to $4,858
million versus $5,024 million in 2010.

“We exited 2011 with good momentum and the outlook for 2012 is even stronger,”
said Kevin Sharer, chairman & CEO at Amgen.  “Our acquisition of Micromet,
announced today, further builds our innovative oncology therapeutics pipeline
and capabilities.”

Adjusted EPS and adjusted net income for the fourth quarter and full year 2011
and 2010 exclude, for the applicable periods, a charge for a legal settlement;
certain expenses related to acquisitions, impairments and cost-savings
initiatives; non-cash interest expense associated with our convertible notes;
the income tax benefit as a result of resolving certain non-routine transfer
pricing issues with tax authorities and certain other items. These adjustments
and other items are presented on the attached reconciliation tables.

On a reported basis in accordance with United States (U.S.) Generally Accepted
Accounting Principles (GAAP), Amgen’s GAAP diluted EPS were $1.08 for the
fourth quarter of 2011, unchanged from the same quarter last year. GAAP net
income of $934 million in the fourth quarter of 2011 decreased 9 percent from
$1,022 million in the same quarter last year.  For the full year 2011, Amgen’s
reported GAAP diluted EPS were $4.04, a decrease of 16 percent compared to
$4.79 for the full year 2010. For the full year 2011, GAAP net income
decreased 20 percent to $3,683 million versus $4,627 million for the full year
2010.  GAAP diluted EPS and net income for the full year 2011 were negatively
impacted by a previously disclosed charge for a legal settlement.

Product Sales Performance

Total product sales increased 4 percent to $3,907 million in the fourth
quarter of 2011 versus $3,760 million in the fourth quarter of 2010.  U.S.
product sales increased 5 percent to $3,007 million in the fourth quarter of
2011 versus $2,869 million in the fourth quarter of 2010. International
product sales increased 1 percent to $900 million in the fourth quarter of
2011 versus $891 million in the fourth quarter of 2010.  Excluding the $28
million unfavorable impact of foreign exchange in the fourth quarter of 2011,
total product sales increased 5 percent and international product sales
increased 4 percent.  For the year, total product sales increased 4 percent to
$15,295 million in 2011 versus $14,660 million in 2010.  U.S. product sales
increased 4 percent to $11,725 million in 2011 versus $11,254 million in 2010.
 International product sales increased 5 percent to $3,570 million in 2011
versus $3,406 million in 2010.  Excluding the $33 million favorable impact of
foreign exchange for the year 2011, total product sales and international
product sales both increased 4 percent.

XGEVA® (denosumab) sales were $134 million in the fourth quarter of 2011, an
increase of 31 percent over the third quarter, and $351 million for the full
year 2011, reflecting increased segment share as well as overall segment
growth.  

Prolia® (denosumab) sales were $81 million in the fourth quarter of 2011, an
increase of 59 percent over the third quarter, and $203 million for the full
year 2011, reflecting significant growth globally.

Combined Neulasta® (pegfilgrastim) and NEUPOGEN® (Filgrastim) sales increased
7 percent to $1,319 million in the fourth quarter of 2011 versus $1,237
million in the fourth quarter of 2010.  Combined U.S. Neulasta and NEUPOGEN
sales increased 12 percent to $1,021 million in the fourth quarter of 2011
versus $914 million in the fourth quarter of 2010, primarily driven by an
increase in the average net sales price, and to a lesser extent, favorable
changes in wholesaler inventories.  Combined Neulasta and NEUPOGEN
international sales decreased 8 percent to $298 million in the fourth quarter
of 2011 versus $323 million in the fourth quarter of 2010.  Excluding the $10
million unfavorable impact of foreign exchange, international Neulasta and
NEUPOGEN product sales decreased 5 percent primarily driven by a NEUPOGEN unit
decline.  For the year, combined Neulasta and NEUPOGEN sales increased 8
percent to $5,212 million in 2011 versus $4,844 million in 2010, principally
driven by an increase in the U.S. average net sales price and Neulasta unit
growth.

Enbrel® (etanercept) sales increased 1 percent to $945 million in the fourth
quarter of 2011 versus $939 million in the fourth quarter 2010, primarily
driven by low single-digit percentage point unit growth, offset partially by
unfavorable changes in wholesaler inventories. For the year, ENBREL sales
increased 5 percent to $3,701 million in 2011 versus $3,534 million in 2010,
primarily driven by an increase in the average net sales price.  ENBREL
remains the segment share leader in both the rheumatology and dermatology
segments.

Aranesp® (darbepoetin alfa) sales decreased 15 percent to $538 million in the
fourth quarter of 2011 versus $633 million in the fourth quarter of 2010. U.S.
Aranesp sales decreased 22 percent to $223 million in the fourth quarter of
2011 versus $285 million in the fourth quarter of 2010, due principally to a
unit decline, offset partially by an increase in the average net sales price.
 The unit decline reflects segment contraction resulting from changes to the
product label and reimbursement environment that occurred  during 2011.
International Aranesp sales decreased 9 percent to $315 million in the fourth
quarter of 2011 versus $348 million in the fourth quarter of 2010.  Excluding
the $12 million unfavorable impact of foreign exchange in the fourth quarter
of 2011, international Aranesp sales decreased 6 percent primarily due to a
unit decline reflecting segment contraction, while share remained stable.  For
the year, worldwide Aranesp sales decreased 7 percent to $2,303 million in
2011 versus $2,486 million in 2010, due principally to a high-teens percentage
point unit decline in the U.S.

EPOGEN® (epoetin alfa) sales decreased 18 percent to $486 million in the
fourth quarter of 2011 versus $591 million in the fourth quarter of 2010. For
the year, EPOGEN sales decreased 19 percent to $2,040 million in 2011 versus
$2,524 million in 2010.  This was due to a decrease in dose utilization
related to changes in reimbursement and the product label, offset partially by
an increase in the average net sales price and patient population growth. 
Relative to the third quarter of 2011, fourth quarter EPOGEN sales increased 2
percent reflecting signs of dose stabilization.

Sales of our other, growth-phase products increased 16 percent to $1,427
million for the full year 2011 as compared to 2010.  Sales of
Sensipar®/Mimpara® (cinacalcet) increased 15 percent to $216 million in the
fourth quarter of 2011 versus $188 million in the fourth quarter of 2010. 
Sales of Vectibix® (panitumumab) increased 10 percent to $87 million in the
fourth quarter of 2011 versus $79 million in the fourth quarter of 2010. 
Sales of Nplate® (romiplostim) increased 23 percent to $80 million in the
fourth quarter of 2011 versus $65 million in the fourth quarter of 2010. For
the year, Sensipar/Mimpara sales increased 13 percent to $808 million in 2011
versus $714 million in 2010, Vectibix sales increased 12 percent to $322
million versus $288 million in 2010, and Nplate sales increased 30 percent to
$297 million versus $229 million in 2010.  These increases were driven
primarily by global unit growth for both the fourth quarter and the full year.

Operating Expense Analysis on an Adjusted Basis:

Cost of sales increased to 16.5 percent of sales in the fourth quarter of 2011
versus 15.1 percent of sales in the fourth quarter of 2010.  Excluding the $79
million impact of the Puerto Rico excise tax, cost of sales would have been
14.4 percent of sales for the quarter, down 0.7 percentage points versus the
fourth quarter of 2010.  For 2011, cost of sales increased to 15.3 percent of
sales versus 15.0 percent of sales in 2010.  Excluding the $211 million impact
of the Puerto Rico excise tax, cost of sales would have been 14.0 percent of
sales for the year, down 1.0 percentage point versus 2010. These decreases
were driven primarily by improved productivity, offset partially by less
favorable product mix.

Research & Development (R&D) expenses increased 2 percent to $842 million in
the fourth quarter of 2011 versus $825 million in the fourth quarter of 2010.
 The increase was due to costs associated with supporting our later stage
clinical programs including AMG 145, talimogene laherparepvec, AMG 386 and
ganitumab (AMG 479).  This increase was largely offset by reduced expenses
related to Discovery Research, Translational Sciences and marketed product
support.  For 2011, R&D expenses were $3,116 million in 2011 versus $2,773
million in 2010, an increase of 12 percent.  This change was primarily due to
increased later stage clinical program support including AMG 386, ganitumab,
talimogene laherparepvec and AMG 145.

Selling, General & Administrative (SG&A) expenses increased 5 percent to
$1,199 million in the fourth quarter of 2011 versus $1,142 million in the
fourth quarter of 2010.  This increase was driven primarily by the U.S.
healthcare reform federal excise fee.  For 2011, SG&A expenses increased 13
percent to $4,434 million versus $3,925 million in 2010.  This increase was
driven primarily by the U.S. healthcare reform federal excise fee, higher
ENBREL profit share expenses, the unfavorable impact of foreign exchange, as
well as increased expenses related to the launches of Prolia and XGEVA and
expansion of our international operations.

The adjusted tax rate for the fourth quarter of 2011 was 14.3 percent compared
with 15.5 percent for the fourth quarter of 2010.  The decrease was due
primarily to the recognition of foreign tax credits associated with the Puerto
Rico excise tax.  This decrease was offset partially by the non-deductible
U.S. healthcare reform federal excise fee and the full-year benefit in the
fourth quarter of 2010 from the enactment of the federal R&D credit.
 Excluding the impact of the Puerto Rico excise tax, the adjusted tax rate for
the fourth quarter of 2011 would have been 18.1 percent.

For 2011, the adjusted tax rate was 14.3 percent compared to 18.8 percent for
2010. The decrease in the full year adjusted tax rate was due primarily to the
aforementioned foreign tax credits associated with the Puerto Rico excise tax
offset partially by the non-deductible U.S. healthcare reform federal excise
fee; excluding the impact of the Puerto Rico excise tax, the adjusted tax rate
for 2011 would have been 19.2 percent.

During the fourth quarter of 2011, Amgen repurchased approximately 86 million
shares of common stock at a total cost of $5.2 billion.  During the fourth
quarter of 2010, Amgen repurchased approximately 20 million shares of common
stock at a total cost of $1.1 billion.  

During 2011, Amgen repurchased approximately 144 million shares of common
stock at a total cost of $8.3 billion and an average price of $57.55.  During
2010, Amgen repurchased approximately 66 million shares of common stock at a
total cost of $3.8 billion and an average price of $57.14.  The Company
currently has $5.0 billion remaining under its authorized stock repurchase
program.

Average diluted shares for adjusted EPS for the fourth quarter of 2011 were
860 million versus 946 million for the fourth quarter of 2010 and 912 million
for the full year 2011 versus 965 million for the full year 2010.

Capital expenditures for the fourth quarter of 2011 were approximately $241
million versus $182 million in the fourth quarter of 2010.  For 2011, capital
expenditures were $584 million versus $580 million in 2010.  Operating cash
flow for 2011 decreased 12 percent to approximately $5.1 billion versus
approximately $5.8 billion in 2010 due primarily to increased interest expense
and working capital increases related to the launches of Prolia and XGEVA.
 Worldwide cash and marketable securities were $20.6 billion and adjusted
outstanding debt was $21.6 billion as of Dec. 31, 2011.

2012 Guidance

The Company expects total revenue for 2012 to be in the range of $16.1 billion
to  $16.5 billion.  Amgen expects 2012 adjusted EPS to be in the range of
$5.90 to $6.15, excluding certain expenses related to acquisitions, the
non-cash interest expense associated with our convertible notes, stock option
expense and certain expenses related to a cost-saving initiative. 

With respect to other guidance, Amgen expects the adjusted tax rate for 2012
to be in the range of 14 percent to 15 percent.  This reflects the impact of
the foreign tax credit associated with the Puerto Rico excise tax.  Excluding
the Puerto Rico excise tax, Amgen expects the adjusted tax rate for 2012 to be
in the range of 19 percent to 20 percent.

The Company expects 2012 capital expenditures to be approximately $700
million.

Fourth Quarter Product and Pipeline Update

The Company provided the following information on selected products and
clinical programs:

XGEVA:  The Company discussed the Oncologic Drugs Advisory Committee (ODAC)
meeting scheduled on Feb. 8, 2012 to review the Supplemental Biologics License
Application (sBLA) to treat men with castration-resistant prostate cancer
(CRPC) at high risk of developing bone metastases.

Vectibix:  The Company discussed the previously announced European Union (EU)
marketing authorization for the treatment of first- and second-line metastatic
colorectal cancer (mCRC).

Prolia:  The Company announced that on Nov. 21, 2011, the sBLA was filed with
the U.S. Food and Drug Administration (FDA) to increase bone mass in men with
osteoporosis at high risk for fracture.  The FDA will target a Prescription
Drug User Fee Act (PDUFA) action date of Sept. 20, 2012.

Nplate:  The Company discussed the FDA modification of the requirements of the
Risk Evaluation and Mitigation Strategy (REMS) Program. Prescribing
physicians, patients and institutions are no longer required to enroll in the
safety monitoring program in order to prescribe or receive Nplate. 

AMG 386:  The Company announced that enrollment has been suspended in the
Phase 3 study in second-line ovarian cancer due to DOXIL® (doxorubicin HCl
liposome injection) supply issues.  Another larger pivotal study in the same
indication continues to enroll.

The Company expects the following clinical data in 2012:

  o Sensipar/Mimpara Phase 3 Evaluation of Cinacalcet Therapy to Lower
    Cardiovascular Events (EVOLVE) study
  o Talimogene laherparepvec Phase 3 melanoma study - interim data for the
    primary endpoint (durable response)
  o AMG 785 - Phase 2 fracture healing studies
  o AMG 145 - Phase 2 studies

Non-GAAP Financial Measures

Management has presented its operating results in accordance with GAAP and on
an “adjusted” (or non-GAAP) basis for the three and twelve months ended Dec.
31, 2011 and 2010. In addition, management has presented its outstanding debt
in accordance with GAAP and on an “adjusted” (or non-GAAP) basis as of Dec.
31, 2011.  The Company believes that the presentation of non-GAAP financial
measures provides useful supplementary information to and facilitates
additional analysis by investors.  The Company uses these non-GAAP financial
measures in connection with its own budgeting and financial planning.  These
non-GAAP financial measures are in addition to, not a substitute for, or
superior to, measures of financial performance prepared in conformity with
GAAP. Further, our reconciliations of GAAP to "adjusted" operating results,
which are included on the attached tables, are presented in the format of
condensed consolidated statements of income solely to facilitate a reader's
understanding of the impact of the various adjustments to our GAAP operating
results, individually and in the aggregate, and are not intended to place any
undue prominence on our adjusted operating results.

About Amgen

Amgen discovers, develops, manufactures and delivers innovative human
therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first
companies to realize the new science’s promise by bringing safe, effective
medicines from lab to manufacturing plant to patient. Amgen therapeutics have
changed the practice of medicine, helping millions of people around the world
in the fight against cancer, kidney disease, rheumatoid arthritis, bone
disease and other serious illnesses. With a deep and broad pipeline of
potential new medicines, Amgen remains committed to advancing science to
dramatically improve people’s lives. To learn more about our pioneering
science and vital medicines, visit www.amgen.com.  Follow us on
www.twitter.com/amgen.

Forward-Looking Statements

This news release contains forward-looking statements that involve significant
risks and uncertainties, including those discussed below and others that can
be found in our Form 10-K for the year ended Dec. 31, 2010, and in our
periodic reports on Form 10-Q and Form 8-K.  Amgen is providing this
information as of the date of this news release and does not undertake any
obligation to update any forward-looking statements contained in this document
as a result of new information, future events or otherwise. 

No forward-looking statement can be guaranteed and actual results may differ
materially from those we project.  The Company’s results may be affected by
our ability to successfully market both new and existing products domestically
and internationally, clinical and regulatory developments (domestic or
foreign) involving current and future products, sales growth of recently
launched products, competition from other products (domestic or foreign) and
difficulties or delays in manufacturing our products.  In addition, sales of
our products are affected by reimbursement policies imposed by third-party
payers, including governments, private insurance plans and managed care
providers and may be affected by regulatory, clinical and guideline
developments and domestic and international trends toward managed care and
health care cost containment as well as U.S. legislation affecting
pharmaceutical pricing and reimbursement.  Government and others’ regulations
and reimbursement policies may affect the development, usage and pricing of
our products.  Furthermore, our research, testing, pricing, marketing and
other operations are subject to extensive regulation by domestic and foreign
government regulatory authorities.  We, or others, could identify safety, side
effects or manufacturing problems with our products after they are on the
market.  Our business may be impacted by government investigations, litigation
and product liability claims.  Further, while we routinely obtain patents for
our products and technology, the protection offered by our patents and patent
applications may be challenged, invalidated or circumvented by our
competitors.  We depend on third parties for a significant portion of our
manufacturing capacity for the supply of certain of our current and future
products and limits on supply may constrain sales of certain of our current
products and product candidate development.  In addition, we compete with
other companies with respect to some of our marketed products as well as for
the discovery and development of new products.  Discovery or identification of
new product candidates cannot be guaranteed and movement from concept to
product is uncertain; consequently, there can be no guarantee that any
particular product candidate will be successful and become a commercial
product.  Further, some raw materials, medical devices and component parts for
our products are supplied by sole third-party suppliers.  Our business
performance could affect or limit the ability of our Board of Directors to
declare a dividend or our ability to pay a dividend or repurchase our common
stock. We may not be able to successfully complete the acquisition of
Micromet, Inc.

DOXIL is a registered trademark of Janssen Biotech Products, LP (formerly
known as Centocor Ortho Biotech Products, LP).

Amgen Inc.
Condensed Consolidated Statements of Income and
Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)
                Three months ended                Three months ended
                December 31, 2011                 December 31, 2010
                GAAP   Adjustments "Adjusted"     GAAP   Adjustments "Adjusted"
Revenues:
                $                                 $
 Product sales  3,907  $    -      $    3,907     3,760  $   -       $    3,760
 Other revenues 66     -           66             81     -           81
    Total
    revenues    3,973  -           3,973          3,841  -           3,841
Operating
expenses:
 Cost of sales
 (excludes
 amortization
 of certain
    acquired
    intangible
    assets
    presented
    below)      656    (13)    (a) 643            572    (4)    (a)  568
 Research and
 development    851    (9)     (b) 842            854    (29)   (b)  825
 Selling,
 general and
 administrative 1,208  (9)     (c) 1,199          1,156  (14)   (c)  1,142
 Amortization
 of certain
 acquired
 intangible
 assets         73     (73)    (d) -              73     (73)   (d)  -
 Other          23     (23)    (e) -              118    (118)  (e)  -
    Total
    operating
    expenses    2,811  (127)       2,684          2,773  (238)       2,535
Operating
income          1,162  127         1,289          1,068  238         1,306
Interest
expense, net    195    (34)    (f) 161            162    (68)   (f)  94
Interest and
other income,
net             84     -           84             93     -           93
Income before
income taxes    1,051  161         1,212          999    306         1,305
Provision
(benefit) for
income taxes    117    56      (g) 173        (h) (23)   225    (g)  202
                $                                 $
Net income       934   $ 105       $    1,039     1,022  $  81       $    1,103
Earnings per
share:
                $                  $              $                  $    
 Basic          1.09                1.22          1.09                1.17
                $                  $              $                  $    
 Diluted (i)    1.08                1.21          1.08                1.17
Average shares
used in
calculation
 of earnings
 per share:
 Basic          854                854            940                940
 Diluted (i)    861                860            946                946

(a) - (i) See explanatory notes on the following pages.

Amgen Inc.
Condensed Consolidated Statements of Income and
Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)
                Year ended                         Year ended
                December 31, 2011                  December 31, 2010
                GAAP    Adjustments "Adjusted"     GAAP    Adjustments "Adjusted"
Revenues:
                $       $                          $
 Product sales  15,295  -           $  15,295      14,660  $    -      $  14,660
 Other revenues 287     -           287            393     -           393
    Total
    revenues    15,582  -           15,582         15,053  -           15,053
Operating
expenses:
 Cost of sales
 (excludes
 amortization
 of certain
    acquired
    intangible
    assets
    presented
    below)      2,427   (82)    (a) 2,345          2,220   (15)    (a) 2,205
 Research and
 development    3,167   (51)    (b) 3,116          2,894   (121)   (b) 2,773
 Selling,
 general and
 administrative 4,486   (52)    (c) 4,434          3,983   (58)    (c) 3,925
 Amortization
 of certain
 acquired
 intangible
 assets         294     (294)   (d) -              294     (294)   (d) -
 Other          896     (896)   (e) -              117     (117)   (e) -
    Total
    operating
    expenses    11,270  (1,375)     9,895          9,508   (605)       8,903
Operating
income          4,312   1,375       5,687          5,545   605         6,150
Interest
expense, net    610     (143)   (f) 467            604     (266)   (f) 338
Interest and
other income,
net             448     -           448            376     -           376
Income before
income taxes    4,150   1,518       5,668          5,317   871         6,188
Provision for
income taxes    467     343     (g) 810        (h) 690     474     (g) 1,164
                $                                  $  
Net income      3,683   $ 1,175     $    4,858     4,627   $ 397       $    5,024
Earnings per
share:
                $                   $              $                   $    
 Basic          4.07                 5.37          4.82                 5.23
                $                   $              $                   $    
 Diluted (i)    4.04                 5.33          4.79                 5.21
Average shares
used in
calculation
 of earnings
 per share:
 Basic          905                 905            960                 960
 Diluted (i)    912                 912            965                 965

(a) - (i) See explanatory notes on the following pages.

Amgen Inc.
Notes to Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)
                                                                                                                                                                   Three months ended     Year ended
                                                                                                                                                                   December 31,           December 31,
                                                                                                                                                                   2011    2010           2011    2010
(a) Adjustments to cost of sales:                                                                                                                                 
                                                                                                                                                                   $       $              $       $        
    Stock option expense (j)                                                                                                                                        (2)        (4)         (10)     (15)
    Incremental expense resulting from accelerating depreciation and accruing losses for facility operating
       leases as a result of our transaction with Boehringer Ingelheim involving our Fremont, California
       manufacturing facility (the BI transaction)                                                                                                                 (11)    -              (65)    -
    Incremental expense resulting from recording inventory acquired at fair value, which is in excess
       of historical cost, in the Laboratorio Quimico Farmaceutico Bergamo Ltd business combination                                                                -       -              (7)     -
                                                                                                                                                                   $       $              $       $        
    Total adjustments to cost of sales                                                                                                                              (13)       (4)         (82)     (15)
(b) Adjustments to research and development expenses:
                                                                                                                                                                   $       $              $       $        
    Stock option expense (j)                                                                                                                                        (8)      (11)          (35)     (51)
    Non-cash amortization of R&D technology intangible assets acquired in business combinations
        in prior years                                                                                                                                             (1)     (18)           (21)    (70)
    Reversal of previously accrued expenses for bonuses and stock-based compensation awards,
        which were forfeited as a result of the employees' termination pursuant to our continuing efforts
        to improve cost efficiencies in our operations                                                                                                             -       -              12      -
    Expense resulting from the cash settlement of unvested employee stock options in connection
       with the BioVex Group, Inc. (BioVex) business combination                                                                                                   -       -              (7)     -
                                                                                                                                                                   $       $              $       $        
    Total adjustments to research and development expenses                                                                                                          (9)      (29)          (51)   (121)
(c) Adjustments to selling, general and administrative expenses:
                                                                                                                                                                   $       $              $       $        
    Stock option expense (j)                                                                                                                                        (8)      (14)          (40)     (58)
    Merger-related expenses associated with certain of our recent business combinations                                                                            (1)     -              (12)    -
                                                                                                                                                                   $       $              $       $        
    Total adjustments to selling, general and administrative expenses                                                                                               (9)      (14)          (52)     (58)
(d) Adjustments to amortization of certain acquired intangible assets:
                                                                                                                                                                   $       $              $       $        
    Non-cash amortization of product technology rights acquired in a prior year business combination                                                                (73)     (73)          (294)  (294)
(e) Adjustments to other operating expenses:
    Certain charges, primarily severance, pursuant to our continuing efforts to improve cost                                                                       $       $              $       $        
        efficiencies in our operations.                                                                                                                             (30)         -         (109)        -
    Asset impairment charge associated with the BI transaction                                                                                                     -       (118)          -       (118)
    Benefit/(expense) resulting from changes in the estimated fair values of the contingent consideration
        obligations related to the BioVex business combination                                                                                                     8       -              (1)     -
    (Expense)/benefit related to certain legal proceedings                                                                                                         (1)     -              (786)   1
                                                                                                                                                                   $       $              $       $        
    Total adjustments to other operating expenses                                                                                                                   (23)   (118)           (896)  (117)
(f) Adjustments to interest expense, net:
                                                                                                                                                                   $       $              $       $        
    Non-cash interest expense associated with our convertible notes                                                                                                 (34)     (68)          (143)  (266)
(g) Adjustments to provision for income taxes:
                                                                                                                                                                   $       $              $       $        
    Income tax effect of the above adjustments (k)                                                                                                                  56      107            331     318
    Income tax benefit related to certain prior period charges excluded from "Adjusted" earnings                                                                   -       5              12      5
    Income tax benefit from resolving certain non-routine transfer pricing issues with tax authorities                                                             -       113            -       151
                                                                                                                                                                   $       $              $       $        
    Total adjustments to provision for income taxes                                                                                                                 56      225            343     474
(h) The "Adjusted" tax rate for the three months and year ended December 31, 2011 was 14.3%, which includes the impact of the Puerto Rico excise tax.
    The following table reconciles the "Adjusted" tax rate including and excluding the Puerto Rico excise tax:
                                                                                                                                                                   Three months ended     Year ended
                                                                                                                                                                   December 31, 2011      December 31, 2011
    "Adjusted" tax rate including Puerto Rico excise tax                                                                                                           14.3%                  14.3%
    Impact of Puerto Rico excise tax                                                                                                                               3.8%                   4.9%
    "Adjusted" tax rate excluding Puerto Rico excise tax                                                                                                           18.1%                  19.2%
(i) The following table presents the computations for GAAP and "Adjusted" diluted EPS, computed under the treasury stock method.
    "Adjusted" EPS presented below excludes stock option expense:
                                                                                                                                                                   Three months ended     Three months ended
                                                                                                                                                                   December 31, 2011      December 31, 2010
                                                                                                                                                                   GAAP    "Adjusted"     GAAP    "Adjusted"
    Income (Numerator):
                                                                                                                                                                   $       $              $       $      
    Net income for basic and diluted EPS                                                                                                                            934    1,039          1,022   1,103
    Shares (Denominator):
    Weighted-average shares for basic EPS                                                                                                                          854     854            940     940
    Effect of dilutive securities                                                                                                                                  7       6          (*) 6       6          (*)
    Weighted-average shares for diluted EPS                                                                                                                        861     860            946     946
                                                                                                                                                                   $       $              $       $        
    Diluted EPS                                                                                                                                                    1.08    1.21           1.08    1.17
                                                                                                                                                                   Year ended             Year ended
                                                                                                                                                                   December 31, 2011      December 31, 2010
                                                                                                                                                                   GAAP    "Adjusted"     GAAP    "Adjusted"
    Income (Numerator):
                                                                                                                                                                   $       $              $       $      
    Net income for basic and diluted EPS                                                                                                                           3,683   4,858          4,627   5,024
    Shares (Denominator):
    Weighted-average shares for basic EPS                                                                                                                          905     905            960     960
    Effect of dilutive securities                                                                                                                                  7       7          (*) 5       5          (*)
    Weighted-average shares for diluted EPS                                                                                                                        912     912            965     965
                                                                                                                                                                   $       $              $       $        
    Diluted earnings per share                                                                                                                                     4.04    5.33           4.79    5.21
    (*)  Dilutive securities used to compute "Adjusted" diluted EPS for the three months and years ended December 31, 2011 and 2010 were computed under the treasury stock method assuming that we do not
    expense stock options.
(j) For the three months and years ended December 31, 2011 and 2010, the total pre-tax expense for employee stock options was $18 million and $85 million, respectively and $29 million and $124 million,
    respectively.
    "Adjusted" diluted EPS including the impact of stock option expense for the three months and years ended December 31, 2011 and 2010 was as follows:
                                                                                                                                                                   Three months ended     Year ended
                                                                                                                                                                   December 31,           December 31,
                                                                                                                                                                   2011    2010           2011    2010
                                                                                                                                                                   $       $              $       $        
    "Adjusted" diluted EPS, excluding stock option expense                                                                                                         1.21    1.17           5.33    5.21
    Impact of stock option expense (net of tax)                                                                                                                    (0.02)  (0.02)         (0.07)  (0.09)
                                                                                                                                                                   $       $              $       $        
    "Adjusted" diluted EPS, including stock option expense                                                                                                         1.19    1.15           5.26    5.12

(k) The tax effect of the adjustments between our GAAP and “Adjusted”
    results takes into account the tax treatment and related tax rate(s)
    that apply to each adjustment in the applicable tax jurisdiction(s).
     Generally, this results in a tax impact at the U.S. marginal tax rate
    for certain adjustments, including amortization of intangible assets and
    non-cash interest expense associated with our convertible notes, whereas
    the tax impact of other adjustments, including the charge for certain
    legal proceedings and stock option expense, depends on whether the
    amounts are deductible in the tax jurisdictions where the expenses are
    incurred or the asset is located and the applicable tax rate(s) in those
    jurisdictions. Due to these factors, the effective tax rates for the
    adjustments to our GAAP results noted in notes (a) - (f) above, for the
    three months and years ended December 31, 2011 and 2010 were 34.8% and
    21.8% and 35.0% and 36.5%, respectively.

Amgen Inc.
Product Sales Detail by Product and Geographic Region
(In millions)
(Unaudited)
                                     Three months ended  Year ended
                                     December 31,        December 31,
                                     2011      2010      2011       2010
Neulasta® - U.S.                     $    770  $    682  $   3,006  $   2,654
NEUPOGEN® - U.S.                     251       232       959        932
Neulasta® - International            228       236       946        904
NEUPOGEN® - International            70        87        301        354
Enbrel® - U.S.                       880       875       3,458      3,304
Enbrel® - Canada                     65        64        243        230
XGEVA® - U.S.                        128       8         343        8
XGEVA® - International               6         -         8          -
Prolia® - U.S.                       52        16        130        26
Prolia® - International              29        4         73         7
Aranesp® - U.S.                      223       285       986        1,103
Aranesp® - International             315       348       1,317      1,383
EPOGEN® - U.S.                       486       591       2,040      2,524
Sensipar® - U.S.                     143       115       518        459
Sensipar® (Mimpara®) - International 73        73        290        255
Vectibix® - U.S.                     31        31        122        115
Vectibix® - International            56        48        200        173
Nplate® - U.S.                       43        34        163        129
Nplate® - International              37        31        134        100
Other - International                21        -         58         -
          Total product sales        $ 3,907   $ 3,760   $ 15,295   $ 14,660
U.S.                                 $ 3,007   $ 2,869   $ 11,725   $ 11,254
International                        900       891       3,570      3,406
          Total product sales        $ 3,907   $ 3,760   $ 15,295   $ 14,660

Amgen Inc.
Condensed Consolidated Balance Sheets - GAAP
(In millions)
(Unaudited)
                                             December 31,   December 31,
                                             2011           2010
Assets
Current assets:
    Cash, cash equivalents and marketable    $          
    securities                               20,641         $          17,422
    Trade receivables, net                   2,896          2,335
    Inventories                              2,484          2,022
    Other current assets                     1,572          1,350
           Total current assets              27,593         23,129
Property, plant and equipment, net           5,420          5,522
Intangible assets, net                       2,584          2,230
Goodwill                                     11,750         11,334
Other assets                                 1,524          1,271
                                             $          
           Total assets                      48,871         $          43,486
Liabilities and Stockholders' Equity
Current liabilities:
                                             $              $          
    Accounts payable and accrued liabilities 5,670           4,082
    Current portion of long-term debt        84             2,488
           Total current liabilities         5,754          6,570
Long-term debt                               21,344         10,874
Other non-current liabilities                2,744          2,098
Stockholders' equity                         19,029         23,944
           Total liabilities and             $          
           stockholders' equity              48,871         $          43,486
Shares outstanding                           796            932

Amgen Inc.
Reconciliation of GAAP Debt Outstanding to "Adjusted" Debt Outstanding
(In millions)
(Unaudited)
                 December 31, 2011
                                 Adjustments for

                                 accounting

                 GAAP            standard                     "Adjusted"
  Total debt     $               $                            $              
  outstanding           21,428       154                  (a)      21,582

    To exclude the impact of adopting an accounting standard on January 1,
(a) 2009 that changed the method of accounting for our convertible notes.

Amgen Inc.
Reconciliation of GAAP EPS Guidance to "Adjusted"
EPS Guidance for the Year Ending December 31, 2012
(Unaudited)
                                                      2012
GAAP EPS (diluted) guidance                           $ 5.43    -    $ 5.70
Known adjustments to arrive at "Adjusted"
earnings*:
              Amortization of acquired
              intangible assets.              (a)                    0.25
              Non-cash interest expense
              associated with our convertible
              notes                           (b)                    0.12
              Stock option expense            (c)     0.05      -    0.07
              Charges associated with the BI
              transaction                     (d)                    0.03
"Adjusted" EPS (diluted) guidance                     $ 5.90    -    $ 6.15
*  The known adjustments are presented net of their related aggregate tax
impact of approximately $0.25 to $0.26 per share.    
(a)  To exclude the ongoing, non-cash amortization of intangible assets
acquired in prior year business combinations.  
(b)  To exclude the non-cash interest expense associated with our convertible
notes.  
(c)  To exclude stock option expense.  
(d)  To exclude incremental expense, related to our cost-saving initiative,
resulting from accelerating depreciation as a result of the BI transaction.  
 On January 26, 2011, we announced that we have entered into a definitive
acquisition agreement to acquire Micromet, Inc.  
 Any resulting adjustments from this transaction have not been determined.
 As a result, no adjustments are included in the table above.  

Reconciliation of GAAP Tax Rate Guidance to "Adjusted"
Tax Rate Guidance for the Year Ending December 31, 2012
(Unaudited)
                                                       2012 without PR excise
                              2012 with PR excise tax  tax
GAAP tax rate guidance        11.7%     -    12.8%        17.3%   -   18.4%
 Tax rate effect of known
 adjustments discussed above  2.2%      -    2.3%         1.6%    -   1.7%
"Adjusted" tax rate guidance  14.0%     -    15.0%        19.0%   -   20.0%

CONTACT:  Amgen, Thousand Oaks
Christine Regan, 805-447-5476 (media)
Arvind Sood, 805-447-1060 (investors)

(Logo:  http://photos.prnewswire.com/prnh/20081015/AMGENLOGO)

SOURCE Amgen

Website: http://www.amgen.com
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