July 1 (Bloomberg) -- Andre Agassi's Wimbledon career ended in a straight-sets defeat to Rafael Nadal as two other Grand Slam tennis winners from the U.S., Andy Roddick and defending women's champion Venus Williams, were upset.

Nadal, the French Open champion and seeded second, downed the 36-year-old Agassi 7-6 (7-5), 6-2, 6-4 in the third round on Centre Court as temperatures rose to about 30 degrees Celsius (86 degrees Fahrenheit) in southwest London today.

Agassi, who won Wimbledon in 1992 after making his debut at the lone grass-court major five years earlier, said last week he was quitting the sport following next month's U.S. Open in New York.

``It's been a privilege to be out there for one last time,'' Agassi, a winner of eight majors, said in his post-match news conference. ``I'll look back at this as one of my most memorable experiences. To say goodbye, for me, this means as much as winning.''

He received a rousing reception from the crowd when he walked into the arena as Steffi Graf, his wife and 22-time Grand Slam champion, watched from the royal box. When the match ended, the British Broadcasting Corp. broke from tradition by conducting a courtside interview, which it normally doesn't do until the final.

Agassi then waved goodbye one last time and signed autographs before leaving. He got another standing ovation from fans, including former British Open champion golfer Ernie Els and England's rugby World Cup-winning coach Clive Woodward.

No Final for Roddick

Third-seeded Roddick, who had lost the last two finals to Roger Federer, was eliminated by the last British player left in the men's draw, Andrew Murray, 7-6 (7-4), 6-4, 6-4.

Murray, ranked 44th, broke Roddick in the final game of the second set and closed out the match on Centre Court when Roddick hit a forehand long. He also won their only other meeting in San Jose, California, this year, where Murray claimed his first top- tier title. Murray, who saved 11 of 12 break points, next faces Australian Open runner-up Marcos Baghdatis.

``I came up with some really big shots on the break points,'' Murray said. ``I wasn't expecting to win.''

Roddick continues to struggle in Grand Slams. Since losing to Federer in the 2005 Wimbledon final, he exited in the first round of the U.S. Open, fourth round of the Australian Open and first round of the French.

``I'm mad, disappointed, whatever other adjectives you want to throw out there,'' Roddick said. ``There's just that intangible quality right now; that edge isn't there. It's what I'm searching for.''

Williams, the sixth seed, made 54 unforced errors and 12 double faults as she lost 7-6 (10-8), 4-6, 6-4, two days after she rallied to advance in three sets against Lisa Raymond.

Williams, limited to five tournaments in 2006 because of an arm injury, squandered set points in the first and led by a break in the third, before she double faulted three times to hand 26th- seeded Jankovic a 5-3 lead. She broke back, but dropped her serve and the match by hitting a shot into the net.

``It's nice to have a lot of matches going into these tournaments,'' said Williams, adding that her left wrist bothered her. ``I could have played better tennis whether or not I had more matches.''

Last American

The defeats leave Shenay Perry as the lone American in the second week in the singles draws.

Maria Sharapova, the 2004 winner, advanced 6-3, 6-2, against Amy Frazier, making her 70th appearance in a Grand Slam, while top-seeded Amelie Mauresmo, the Australian Open champion, beat qualifier Nicole Pratt 6-1, 6-2.

The 20-year-old Nadal came back from 5-2 down in the first- set tiebreak after 25th-seeded Agassi saved three set points and three other break points on his serve. The opening set lasted 63 minutes.

At 5-4 in the tiebreak, Agassi hit a short forehand inches wide down the line. On the next point, the crowd gasped as Nadal delivered a running cross-court passing shot from yards behind the baseline. He closed out the set with one of his 17 aces.

``Once the first set was gone, sort of, the prospects got grimmer for me,'' Agassi said. ``His movement is out of this world.''

Nadal broke Agassi to start the second with a forehand that clipped the baseline and broke again to take a 5-2 lead. Nadal, who never faced a break point, cracked an ace to end the second.

The only break of the third came at 3-3, when Agassi sent a backhand long. The crowd cheered Agassi again when he walked to his side of the court following a changeover at 4-5, though Nadal closed out the match with another ace.

Next for Nadal

Nadal faces qualifier Irakli Labadze in two days. Labadze advanced when opponent Mardy Fish retired with a stomach illness after losing the first set.

Lleyton Hewitt, the 2002 champion, advanced with a straight- sets win over Olivier Rochus, while 27th-seeded Dmitry Tursunov saved a match point and came back from two sets down to beat fifth-seeded Ivan Ljubicic 6-2 in the final set. No. 23 David Ferrer also rallied from two sets down to beat No. 10 Fernando Gonzalez. Mario Ancic, the seventh seed, and No. 22 Jarkko Nieminen also progressed.

Other women's seeds to advance included: No. 7 Elena Dementieva, No. 9 Anastasia Myskina, No. 16 Flavia Pennetta, and No. 19 Ana Ivanovic.

To contact the reporter on this story: Ravi Ubha at Wimbledon through the London office at at rubha@bloomberg.net

Last Updated: July 1, 2006 16:59 EDT